Software tool for constructing and using semantically sound data dictionaries
| developed by |
clinical domains |
keywords |
| Onto-Med Research Group, Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany |
Malignant Lymphoma,
Heart Failure, Pediatric Oncology |
Ontologies in Medicine, data dictionaries, metalogical, conceptual modelling, GOL, SOP-Creator |
| status |
access demonstrator |
| Under continued development and refinement. In use by the Research Networks on Malignant Lymphoma and Heart Failure and the Coordination Center for Clinical Trials, Leipzig (KKSL). |
|
| description |
| Onto-Builder is a tool designed to support the
construction and administration of Data
Dictionaries in the field of clinical trials.
A standard Data Dictionary used in the collection and analysis of clinical trials data supports:
- "reusability of terms and their meanings, e.g. in the definition of new trials
- uniform reference of terms for all trial-specific tools, input windows
- uniform reference of terms for the definition of Standard Operating Procedures (SOPs) within the Lymphoma
Alliance
- quality assurance in carrying out clinical trials
- comparison of differing definitions of a term in various sources, thereby supporting comparative analysis
and consensus building
- harmonization of the study-center databases within the Lymphoma Alliance
- harmonization of trial protocols and case report forms"
|
| references |
| Heller B, Herre H, Lippoldt K, Loeffler M.
Standardized terminology for clinical trial protocols based on top-level ontological categories.
Stud Health Technol Inform. 2004;101:46-60.
[PubMed]
[]
|
"This paper describes a new method for the ontologically based standardization of concepts with regard to the quality assurance of clinical trial protocols. We developed a data dictionary for medical and trial-specific terms in which concepts and relations are defined context-dependently. The data dictionary is provided to different medical research networks by means of the software tool Onto-Builder via the internet. The data dictionary is based on domain-specific ontologies and the top-level ontology of GOL. The concepts and relations described in the data dictionary are represented in natural language, semi-formally or formally according to their use. " |
Heller, B., Herre, H., Lippoldt, K., Löffler, M. 2004. Standardized Terminology for Clinical Trial Protocols Based on Ontological Top-Level Categories. In: Kaiser, K., Miksch, S., Tu, S.W. (eds.) Computer-based Support for Clinical Guidelines and Protocols. Proceedings of the Symposium on Computerized Guidelines and Protocols. (CGP 2004), 2004 April 13-14. Prague. p. 46-60. Studies in Health Technology and Informatics, Vol.101. Amsterdam: IOS-Press
[]
[IMISE]
|
"
This paper describes a new method for the ontologically based standardization
of concepts with regard to the quality assurance of clinical trial protocols. We
developed a data dictionary for medical and trial-specific terms in which concepts
and relations are defined context-dependently. The data dictionary is provided to different
medical research networks by means of the software tool Onto-Builder via the
internet. The data dictionary is based on domain-specific ontologies and the toplevel
ontology of GOL1. The concepts and relations described in the data dictionary
are represented in natural language, semi formally or formally according to their use.
"
|
|
| contact |
links |
Dr. Barbara Heller, Prof. Heinrich Herre, Prof. Markus Loeffler
IMISE
University Leipzig
Härtelstr. 16-18
04107 Leipzig
Germany.
Tel.: +49 (0) 341 97 16 104
F: +49 (0) 341 97 16130
E: barbara.heller@imise.uni- leipzig.de
|
|
| acknowledgements |
| |
Entry on OpenClinical: 09 February 2005
Last main update: 09 February 2005
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Onto-Builder
Demonstration version of Onto-Builder - registration required