Interpretation of hepatitis serology findings
| developed by |
clinical domains |
keywords |
| Department of Medical Computer Sciences, University of Vienna and the University Clinic of Gastroenterology and Hepatology. |
hepatitis, laboratory |
Medical expert system; Laboratory interpretive system, quality assurance, WWW |
| status |
access demonstrator |
| |
|
| description |
| "The knowledge base of HEPAXPERT-III contains 16 rules for hepatitis A and 131 rules for hepatitis B serology. By using this knowledge base, each of the 64 and 57344 possible serologic finding patterns, respectively, of the antigen and antibody tests for hepatitis A and B serology can be interpreted including analysis of possible virus exposition, immunity, disease stage, prognosis, and degree of infectiousness."
"Besides the automated interpretation of rare and complex combinations of hepatitis serology test results, Hepaxpert also contributes to quality control in the laboratory. It does not only indicate improbable or even impossible combinations of test results but also provides useful information on the diagnostic value of further serologic tests. " |
| references |
|
Adlassnig KP, Chizzali-Bonfadin C, Kreihsl M, Schulz F, Horak W, Hofmann H.
HEPAXPERT-III: knowledge-based interpretation of serologic tests for hepatitis A, B, C, and D
Medinfo 1995;8 Pt 2:1683.
[PubMed]
|
"
HEPAXPERT-III--the successor of HEPAXPERT-I[1] and HEPAXPERT-II [2]--is a routinely-used, integrated medical database and knowledge-based system that stores and interprets the results of serologic tests for infection with hepatitis A, B, C, and D viruses. The following tests are included: Anti-HAV, IGM anti-HAV, and HAV in stool; HBsAg, anti-HBs, anti-HBc, IGM anti-HBc, HBeAg, anti-HBe, and anti-HBs titre; Anti-HCV, HCV-immunoblot, and HCV-PCR; Delta-Ag and anti-delta. HEPAXPERT-III provides the following functions: a) screen input of patient's personal data (patient ID, surname, first name, name at birth, date of birth, and sex), administrative data (department requiring the tests and date of specimen sample), and medical data (results of serologic tests); and/or b) automatic transfer of patient's personal, administrative, and medical data by connecting HEPAXPERT-III to a laboratory information system, a hospital information system, or an automated laboratory analyzer; and c) automatic generation of interpretive reports of the obtained serologic findings, including an analysis of possible virus exposition, immunity, disease stage, prognosis, and degree of infectiousness. HEPAXPERT-I and HEPAXPERT-II have been routinely used at the Vienna General Hospital, the teaching hospital of the University of Vienna Medical School. The interpretive reports are well-accepted and lead to several improvements in patient care [3]. HEPAXPERT-III will not only extend the scope of interpretation to hepatitis C and D serologic tests, but will also offer a state-of-the-art graphical user interface. 2. HARDWARE AND SOFTWARE. IBM-compatible personal computer (minimum 80386 SX processor), 8 MB RAM (OS/2) and 4 RM RAM (MS-Windows), resp., graphic adapter (minimum 640x480) and printer supported by OS/2 and MS-Windows 3.1, resp., IBM OS/2-2.1 or higher and MS-Windows 3.1 or higher, resp., and for the OS/2 version IBM Database 2 (DB2/2).
"
|
|
| contact |
links |
Prof. Klaus-Peter Adlassnig
Section on Medical Expert and Knowledge-Based Systems
Department of Medical Computer Sciences
Medical University of Vienna
Austria
|
|
| acknowledgements |
| |
Entry on OpenClinical: 27 January 2005
Last main update: 30 January 2005
|
|
Hepaxpert III / WWW
Hepaxpert III / WWW - in German [mit Bedienung]
Hepaxpert III / WWW - in English [with User Guide]
Demonstration and background information on HEPAXPERT III/WWW