Hepaxpert I is a stand alone program with no direct connection to an external data source. Hepaxpert II is a database and interpretive system providing database management and download functions as well.It can be connected directly to a laboratory information system, a hospital information system or an automated laboratory analyzer. Hepaxpert III is a WWW implementation of Hepaxpert.

Adlassnig KP, Chizzali-Bonfadin C, Kreihsl M, Schulz F, Horak W, Hofmann H. HEPAXPERT-III: knowledge-based interpretation of serologic tests for hepatitis A, B, C, and D Medinfo 1995;8 Pt 2:1683. [PubMed]

" The HEPAXPERT-III SYSTEM. HEPAXPERT-III--the successor of HEPAXPERT-I[1] and HEPAXPERT-II [2]--is a routinely-used, integrated medical database and knowledge-based system that stores and interprets the results of serologic tests for infection with hepatitis A, B, C, and D viruses. The following tests are included: Anti-HAV, IGM anti-HAV, and HAV in stool; HBsAg, anti-HBs, anti-HBc, IGM anti-HBc, HBeAg, anti-HBe, and anti-HBs titre; Anti-HCV, HCV-immunoblot, and HCV-PCR; Delta-Ag and anti-delta. HEPAXPERT-III provides the following functions: a) screen input of patient's personal data (patient ID, surname, first name, name at birth, date of birth, and sex), administrative data (department requiring the tests and date of specimen sample), and medical data (results of serologic tests); and/or b) automatic transfer of patient's personal, administrative, and medical data by connecting HEPAXPERT-III to a laboratory information system, a hospital information system, or an automated laboratory analyzer; and c) automatic generation of interpretive reports of the obtained serologic findings, including an analysis of possible virus exposition, immunity, disease stage, prognosis, and degree of infectiousness. HEPAXPERT-I and HEPAXPERT-II have been routinely used at the Vienna General Hospital, the teaching hospital of the University of Vienna Medical School. The interpretive reports are well-accepted and lead to several improvements in patient care [3]. HEPAXPERT-III will not only extend the scope of interpretation to hepatitis C and D serologic tests, but will also offer a state-of-the-art graphical user interface. 2. HARDWARE AND SOFTWARE. IBM-compatible personal computer (minimum 80386 SX processor), 8 MB RAM (OS/2) and 4 RM RAM (MS-Windows), resp., graphic adapter (minimum 640x480) and printer supported by OS/2 and MS-Windows 3.1, resp., IBM OS/2-2.1 or higher and MS-Windows 3.1 or higher, resp., and for the OS/2 version IBM Database 2 (DB2/2). "

Adlassnig KP, Horak W. Development and retrospective evaluation of Hepaxpert-I: a routinely-used expert system for interpretive analysis of hepatitis A and B serologic findings. Artif Intell Med. 1995 Feb;7(1):1-24. [PubMed]   [ScienceDirect]

" Hepaxpert-I is an expert system that interprets the results of routine serologic tests for infection with hepatitis A or B virus. The tests measure antibody to the hepatitis A virus (anti-HAV), IgM antibody to the hepatitis A virus (IgM anti-HAV), hepatitis A virus (HAV) in the stool, hepatitis B surface antigen (HBsAg) and antibody (anti-HBs), antibody to hepatitis B core antigen (anti-HBc and IgM anti-HBc), and hepatitis B envelope antigen (HBeAg) and antibody (anti-HBe). The knowledge base of Hepaxpert-I contains 13 If-Then rules for hepatitis A and 106 If-Then rules for hepatitis B serology. Formally, knowledge acquisition was done by forming a partition of each of the two sets of possible serologic finding patterns that contain patterns of serologic test results, 64 for hepatitis A and 4096 for hepatitis B, respectively. After entering an input pattern of serologic test results in Hepaxpert-I, a rule pattern matching algorithm based on indexing is internally employed as efficient access method for providing the respective interpretive text. Since 1 September 1989, Hepaxpert-I has been routinely applied at the Hepatitis Serology Laboratory of the 2nd Department of Gastroenterology and Hepatology at the University of Vienna Medical School (Vienna General Hospital). Beforehand, a retrospective evaluation of the expert system based on 23,368 hepatitis A and 24,071 hepatitis B serology requests was carried out. "

Adlassnig KP, Horak W. Hepaxpert-1: Automatic interpretation of tests for hepatitis a and B. MD Comput 1991 Mar-Apr;8(2):118-9

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KP Adlassnig, W Horak, Routinely-used, automated interpretive analysis of hepatitis A and B serology findings by a medical expert system, Proc. Medical Informatic Europe `90, R. O'Moore et al. (eds), Lecture Notes in Medical Informatics, 40, Springer-Verlag, 313-318.

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Archive of AI systems in clinical practice previously administered by Enrico Coiera. Used with permission. Maintained and extended since 2001 by OpenClinical.